1. Product Description
- Name: G-Lanso 30mg (Lansoperazole)
- Type: Proton Pump Inhibitor (PPI)
- Form: Oral capsule
- Strength: 30 mg per capsule
2. Chemical Information
- Chemical Name: Lansoprazole
- Molecular Formula: C16_{16}16H14_{14}14F3_{3}3N3_{3}3O2_{2}2
- Molecular Weight: Approximately 369.3 g/mol
3. Indications
- Primary Uses:
- Treatment of gastroesophageal reflux disease (GERD)
- Healing of erosive esophagitis caused by GERD
- Management of Zollinger-Ellison syndrome (a condition with excessive stomach acid production)
- Treatment of peptic ulcers, including those associated with Helicobacter pylori infection, often in combination with antibiotics
- Prevention of NSAID-induced gastric ulcers in patients at risk
4. Dosage and Administration
- Dosage Form:
- 30 mg Capsules: For various conditions as listed below.
- Typical Dosage Schedule:
- 30 mg: Usually taken once daily before a meal. For some conditions, the dose may be adjusted or taken twice daily as prescribed by a healthcare provider.
- Administration: Swallow capsules whole with a full glass of water. Do not crush, chew, or break the capsules.
5. Pharmacokinetics
- Absorption: Lansoprazole is well absorbed from the gastrointestinal tract. Peak plasma concentrations are typically reached within 1 to 2 hours after oral administration.
- Distribution: Extensively bound to plasma proteins.
- Metabolism: Metabolized primarily in the liver by the cytochrome P450 enzyme system (CYP2C19 and CYP3A4).
- Excretion: Excreted mainly in the urine, with a smaller amount eliminated via bile.
6. Side Effects
- Common Side Effects:
- Gastrointestinal symptoms (e.g., nausea, diarrhea, constipation)
- Headache
- Dizziness
- Serious Side Effects:
- Risk of Clostridium difficile infection in the colon
- Risk of bone fractures with long-term use
- Renal issues (e.g., acute interstitial nephritis)
- Hypomagnesemia (low magnesium levels)
7. Contraindications
- Known Allergies: Hypersensitivity to lansoprazole or other PPIs.
- Liver Disease: Severe hepatic impairment may require dose adjustments or alternative treatments.
- Drug Interactions: Caution with drugs metabolized by CYP2C19 and CYP3A4 enzymes.
8. Precautions
- Caution: Use with caution in patients with a history of liver disease, renal impairment, or those who are pregnant or breastfeeding.
- Drug Interactions: Inform your healthcare provider about all medications you are taking, as lansoprazole may interact with drugs metabolized by CYP2C19 and CYP3A4.
- Monitoring: Long-term use may require monitoring of magnesium levels and bone density.
9. Storage
- Conditions: Store at room temperature, away from moisture and heat.
- Packaging: Typically found in blister packs or bottles with child-resistant caps.
10. Patient Counseling Information
- Adherence: Take as prescribed and do not exceed the recommended dose.
- Timing: Best taken before a meal, usually in the morning.
- Report Symptoms: Notify your healthcare provider if you experience severe side effects or signs of an allergic reaction, such as rash, itching, or swelling.